PRESS RELEASE – TEDCO Announces New Board Director, Jennifer Elisseeff

TEDCO Announces New Board Director

Johns Hopkins’ Jennifer Elisseeff

COLUMBIA, Md. (April 13, 2017) – The Maryland Technology Development Corporation (TEDCO) announced today that Governor Larry Hogan appointed Dr. Jennifer Elisseeff of Johns Hopkins University (JHU) to the Board of Directors.

Dr. Elisseeff is the Morton Goldberg Professor and director of the Translational Tissue Engineering Center at Wilmer Eye Institute and the Department of Biomedical Engineering at JHU. In 2004, Elisseeff cofounded Cartilix, Inc, a startup that translated adhesive and biomaterial technologies for treating orthopedic disease, acquired by Biomet Inc in 2009. Also in that year, she founded Aegeria Soft Tissue, a startup focused on soft tissue regeneration and wound healing. She is a member of the National Academy of Inventors (and advises a number of biotech companies around the country).

“We are pleased to welcome Dr. Elisseeff to TEDCO’s board of directors,” said Newt Fowler, TEDCO Board Chair and business transactions partner of Womble Carlyle, LLP. “Our goal is to provide the support and resources to TEDCO executives, helping them continue to spur economic development and remain as the go-to funding source for Maryland start-up companies. Dr. Elisseeff’s experience and insight not only as a leading researcher but as an entrepreneur involved in many biotech companies located on both the East and West Coasts, will prove an incredible benefit not only to TEDCO but more importantly to our life science companies.”

TEDCO is governed by a board, which is appointed by the Governor for four-year terms with the consent of the Maryland State Senate. Last year, Governor Hogan appointed/reappointed 15 members to TEDCO’s board of directors.

Current TEDCO board of directors are: Chair Newt Fowler, Womble Carlyle, LLP; Vice Chair Francis Smyth, Century Engineering; Secretary Matthew Lee, FASTech; Treasurer Luke Cooper, Fixt; Paul Ausley, Ausley Associates; Chris Brandenburg, Kilkea Charles, LLC; Ray Hoy, Wor-Wic College; Chuck Knudsen, T. Rowe Price; Omar Muhammad, Morgan State University; C. Warren Mullins; Marty Roesch, Cisco/Sourcefire; John Shetrone, Vision Technologies; Amita Shukla, Vitamita; and Michael Gill, Maryland Department of Commerce.

“We welcome Dr. Elisseeff to a dedicated and talented board,” said John Wasilisin, president and chief operating officer of TEDCO. “We look forward to her contributions in fostering TEDCO’s mission to support seed/early-stage innovation and promote entrepreneurship in Maryland.”

TEDCO board members must be residents of the state and represent the nonprofit research sector, venture capital financing, technology-based businesses, the general public and colleges or universities. For the full list of TEDCO’s board of directors, click here.

The Maryland Technology Development Corporation (TEDCO) is the go-to source for entrepreneurial support and guidance for start-ups and early-stage companies engaged in bringing innovative ideas to market. For over eighteen years, the organization has provided funding, mentoring and networking opportunities to support Maryland’s innovation ecosystem. It is frequently ranked as one of the most active seed/early-stage investors in the nation. The organization plays a key role in bringing research created in Maryland’s educational institutions and federal laboratories into the commercial marketplace. For more information about TEDCO and its programs and resources, visit www.TEDCO.md.

February News

Qiaozhi ‘Nicole’ Lu celebrates her last day in the Elisseeff lab, leaving to the University of Pennsylvania as a Postdoctoral Fellow

Okhee Jeon had a paper accepted to Nature Medicine.

 

Nathaniel Hwang gives a talk to the Elisseeff lab.

PRESS RELEASE from Mary Ann Liebert, Inc., Publishers

Making Metabolically Active Brown Fat from White Fat-Derived Stem Cells

New Rochelle, NY, March 3, 2017—Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells (ASCs). The study describes a method to produce brown fat tissue, which exists in only small amounts in adults, and is published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until April 3, 2017.

Jennifer Elisseeff, Jessica Yang, and coauthors from Johns Hopkins University, Johns Hopkins School of Medicine (Baltimore, MD), and Ecole Polytechnique (Palaiseau, France) used a “browning” process to trigger the transition of mature adipocytes generated from white ASCs into brown adipocytes. The brown adipocytes exhibited the increased metabolic activity characteristic of brown fat tissue. The researchers report their method and results in the article entitled “Metabolically Active Three-Dimensional Brown Adipose Tissue Engineered from White Adipose-Derived Stem Cells.”

“Scientists are discovering novel ways to engineer the adipose system to leverage its ‘stemness’ and now, its metabolic phenotype. These two approaches will provide substantial opportunities in the treatment of disease,” says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Kaitlyn Sadtler, PhD – Published in Science

Engineering a healing immune response

Infections, surgeries, and trauma can all cause major tissue damage. Biomaterial scaffolds, which help to guide regenerating tissue, are an exciting emerging therapeutic strategy to promote tissue repair. Sadtler et al. tested how biomaterial scaffolds interact with the immune system in damaged tissue to promote repair (see the Perspective by Badylak). Scaffolds derived from cardiac muscle and bone extracellular matrix components trigger a tissue-reparative T cell immune response in mice with injured muscles.

Science, this issue p. 366; see also p. 298

 

Dr. Jennifer Elisseeff, appointed the Morton Goldberg Professor of Ophthalmology at the Wilmer Eye Institute.

August, 2016 – Acceptance of the Morton Goldberg, MD Professorship in Ophthalmology at the Wilmer Eye Institute, Johns Hopkins University.

“Bench to Bedside: Moving Science Fiction into Scientific Discovery”

CONGRATULATIONS and BEST WISHES

Congratulations to Jake Simson who recently graduated and received his PhD from The Johns Hopkins University. He will be leaving Dr. Elisseeff’s lab mid June to pursue his career.

Best wishes to Tara Deans who has been a Postdoc here in the Elisseeff Lab over the past several years. She will be leaving the Elisseeff Lab at the end of May.

We wish Jake and Tara much success!

President’s Circle of the National Academies

In May 2012 Dr. Elisseeff attended the President’s Circle at the National Academy in DC, a stimulating event with speakers discussing topics ranging from energy, nuclear, design, and STEM education.

Jay Walker entertains during a small group discussion. Photo courtesy Christopher Michel.

Promotion Lecture and Reception

Reminiscing about the past 15 years of research and thanks to students, colleagues, mentors, and collaborators.  Watch the video at:  http://webcast.jhu.edu/mediasite/Viewer/?peid=4568f5289c7b4921a934d303d8dd637c1

2011 Provosts Lecture Series: Jennifer H. Elisseeff, Phd at Johns Hopkins University

Dr. Jennifer Elisseeff, Associate Professor, Jules Stein Chair in Ophthalmology Wilmer Eye Institute, Director of Translational Tissue Engineering Center, Department of Biomedical Engineering, Department of Orthopedic Surgery, Department of Materials Science and Engineering will discuss the materials in Medicine: From Tools to Translational Tissue Engineering from 5:00 pm-7:00 pm on November 21 in Feinstone Hall, E2030 (BSPH). Q & A and reception immediately following. RSVP:ProvostRSVP@jhu.eduThe Provosts Lecture Series, launched in 2010 to spread the wealth of academic excellence at Johns Hopkins among its campuses. The theme of this years lecture series will be innovation, highlighting the unique role of research universities in fostering innovative thinking and creative solutions to some of the worlds greatest challenges.
Watch the lecture:

New composite material may restore damaged soft tissue

Step 1

Potential uses include facial reconstruction for soldiers’ blast injuries

Biomedical engineers at Johns Hopkins have developed a new liquid material that in early experiments in rats and humans shows promise inrestoring damaged soft tissue relatively safely and durably. The material, a composite of biological and synthetic molecules, is injected under the skin, then “set” using light to form a more solid structure, like using cold to set gelatin in a mold. The researchers say the product one day could be used to reconstruct soldiers’ faces marred by blast injuries.

The Johns Hopkins researchers caution that the material, described in a report in the July 27 issue of Science Translational Medicine, is “promising,” but not yet ready for widespread clinical use.

Implanted biological materials can mimic the texture of soft tissue, but are usually broken down by the body too fast, while synthetic materials tend to be more permanent but can be rejected by the immune system and typically don’t meld well with surrounding natural tissue,” says Jennifer Elisseeff, Ph.D., Jules Stein Professor of Ophthalmology and director of the Translational Tissue Engineering Center at the Johns Hopkins University School of Medicine. “Our composite material has the best of both worlds, with the biological component enhancing compatibility with the body and the synthetic component contributing to durability.”

The researchers created their composite material from hyaluronic acid (HA), a natural component in skin of young people that confers elasticity, and polyethylene glycol (PEG), a synthetic molecule used successfully as surgical glue in operations and known not to cause severe immune reactions. [Read more…]